VIP papers
Papers authored/coauthored by the VIP-network and from the VIP1, VIP2 and COVIP studies.
Short-term mortality of patients ≥80 years old admitted to European intensive care units: an international observational study
Fronczek J, Flaatten H, Guidet B, Polok K, Andersen FH, Andrew BY, Artigas A, Beil M, Cecconi M, Christensen S, de Lange DW, Fjølner J, Górka J, Joannidis M, Jung C, Kusza K, Leaver S, Marsh B, Morandi A, Moreno R, Oeyen S, Owczuk R, Agvald-Öhman C, Pinto BB, Rhodes A, Schefold JC, Soliman IW, Valentin A, Walther
S, Watson X, Zafeiridis T, Szczeklik W; VIP1 & VIP2 study group
Variations in end-of-life care practices in older critically ill patients with COVID-19 in Europe
Wernly B, Rezar R, Flaatten H, Beil M, Fjølner J, Bruno RR, Artigas A, Pinto
BB, Schefold JC, Kelm M, Sigal S, van Heerden PV, Szczeklik W, Elhadi M,
Joannidis M, Oeyen S, Wolff G, Marsh B, Andersen FH, Moreno R, Leaver S, Wernly
S, Boumendil A, De Lange DW, Guidet B, Jung C
Association of chronic heart failure with mortality in old intensive care patients suffering from Covid-19
Bruno RR, Wernly B, Wolff G, Fjølner J, Artigas A, Bollen Pinto B, Schefold
JC, Kindgen-Milles D, Baldia PH, Kelm M, Beil M, Sviri S, van Heerden PV,
Szczeklik W, Topeli A, Elhadi M, Joannidis M, Oeyen S, Kondili E, Marsh B,
Andersen FH, Moreno R, Leaver S, Boumendil A, De Lange DW, Guidet B, Flaatten H,
Jung C; COVIP study group
The association of the Activities of Daily Living and the outcome of old intensive care patients suffering from COVID-19
Bruno RR, Wernly B, Flaatten H, Fjølner J, Artigas A, Baldia PH, Binneboessel
S, Bollen Pinto B, Schefold JC, Wolff G, Kelm M, Beil M, Sviri S, van Heerden
PV, Szczeklik W, Elhadi M, Joannidis M, Oeyen S, Kondili E, Marsh B, Wollborn J,
Andersen FH, Moreno R, Leaver S, Boumendil A, De Lange DW, Guidet B, Jung C;
COVIP study group
Annals of Intensive Care. 2022-03-18;12PubmedCOVIP
Increased 30-day mortality in very old ICU patients with COVID-19 compared to patients with respiratory failure without COVID-19
Guidet B, Jung C, Flaatten H, Fjølner J, Artigas A, Pinto BB, Schefold JC, Beil M, Sigal S, van Heerden PV, Szczeklik W, Joannidis M, Oeyen S, Kondili E, Marsh B, Andersen FH, Moreno R, Cecconi M, Leaver S, De Lange DW, Boumendil A;
VIP2 and COVIP study groups
Health-related quality of life in older patients surviving ICU treatment for COVID-19: results from an international observational study of patients older than 70 years
Soliman IW, Leaver S, Flaatten H, Fjølner J, Wernly B, Bruno RR, Artigas A,
Bollen Pinto B, Schefold JC, Beil M, Sviri S, van Heerden PV, Szczeklik W,
Elhadi M, Joannidis M, Oeyen S, Zafeiridis T, Wollborn J, Banzo MJA, Fuest K,
Marsh B, Andersen FH, Moreno R, Boumendil A, Guidet B, Jung C, De Lange DW;
COVIP-study group
The clinical frailty scale - does it predict outcome of the very-old in UK ICUs?
Dagan O Lonsdale, Liting Tong, Helen Farrah, Sarah Farnell-Ward, Chris Ryan, Ximena Watson, Maurizio Cecconi, Hans Flaatten, Jesper Fjølner, Christian Jung, Bertrand Guidet, Dylan de Lange, Wojciech Szczeklik, Johanna M Muessig, Susannah K Leaver
Association between tracheostomy timing and outcomes for older critically ill COVID-19 patients: prospective observational study in European intensive care units
Polok K, Fronczek J, van Heerden PV, Flaatten H, Guidet B, De Lange DW, Fjølner J, Leaver S, Beil M, Sviri S, Bruno RR, Wernly B, Artigas A, Pinto BB, Schefold JC, Studzińska D, Joannidis M, Oeyen S, Marsh B, Andersen FH, Moreno R, Cecconi M, Jung C, Szczeklik W; COVIP study group
The importance of revealing data on limitation of life sustaining therapy in critical ill elderly Covid-19 patients
Flaatten H, Guidet B, de Lange DW, Beil M, Leaver SK, Fjølner J, van Heerden
PV, Sigal S, Szczeklik W, Jung C
Management and outcomes in critically ill nonagenarian versus octogenarian patients
Bruno RR, Wernly B, Kelm M, Boumendil A, Morandi A, Andersen FH, Artigas A,
Finazzi S, Cecconi M, Christensen S, Faraldi L, Lichtenauer M, Muessig JM, Marsh
B, Moreno R, Oeyen S, Öhman CA, Pinto BB, Soliman IW, Szczeklik W, Valentin A,
Watson X, Leaver S, Boulanger C, Walther S, Schefold JC, Joannidis M, Nalapko Y,
Elhadi M, Fjølner J, Zafeiridis T, De Lange DW, Guidet B, Flaatten H, Jung C;
VIP2 study group
Differences in mortality in critically ill elderly patients during the second COVID-19 surge in Europe
Jung C, Fjølner J, Bruno RR, Wernly B, Artigas A, Bollen Pinto B, Schefold
JC, Wolff G, Kelm M, Beil M, Sviri S, van Heerden PV, Szczeklik W, Czuczwar M,
Joannidis M, Oeyen S, Zafeiridis T, Andersen FH, Moreno R, Leaver S, Boumendil
A, De Lange DW, Guidet B, Flaatten H; , COVIP Study Group
The management of multi-morbidity in elderly patients: Ready yet for precision medicine in intensive care?
Beil M, Flaatten H, Guidet B, Sviri S, Jung C, de Lange D, Leaver S, Fjølner
J, Szczeklik W, van Heerden PV
Critical Care. 2021-09-10PubmedFree full text link
Early evaluation of organ failure using MELD-XI in critically ill elderly COVID-19 patients
Bruno RR, Wernly B, Hornemann J, Flaatten H, FjØlner J, Artigas A, Bollen
Pinto B, Schefold JC, Wolff G, Baldia PH, Binneboessel S, Kelm M, Beil M, Sviri
S, van Heerden PV, Szczeklik W, Elhadi M, Joannidis M, Oeyen S, Kondili E,
Wollborn J, Marsh B, Andersen FH, Moreno R, Leaver S, Boumendil A, De Lange DW,
Guidet B, Jung C; COVIP study group
Clin Hemorheol Microcirc. 2021-08-28PubmedCOVIP
Lactate is associated with mortality in very old intensive care patients suffering from COVID-19: results from an international observational study of 2860 patients
Bruno RR, Wernly B, Flaatten H, Fjølner J, Artigas A, Bollen Pinto B,
Schefold JC, Binnebössel S, Baldia PH, Kelm M, Beil M, Sigal S, van Heerden PV,
Szczeklik W, Elhadi M, Joannidis M, Oeyen S, Zafeiridis T, Wollborn J, Arche
Banzo MJ, Fuest K, Marsh B, Andersen FH, Moreno R, Leaver S, Boumendil A, De
Lange DW, Guidet B, Jung C; COVIP Study Group
Annals of Intensive Care. 2021-08-21PubmedCOVIP
ICU-Mortality in Old and Very Old Patients Suffering From Sepsis and Septic Shock
Bruno RR, Wernly B, Mamandipoor B, Rezar R, Binnebössel S, Baldia PH, Wolff
G, Kelm M, Guidet B, De Lange DW, Dankl D, Koköfer A, Danninger T, Szczeklik W,
Sigal S, van Heerden PV, Beil M, Fjølner J, Leaver S, Flaatten H, Osmani V, Jung
C
Relationship between the Clinical Frailty Scale and short-term mortality in patients ≥ 80 years old acutely admitted to the ICU: a prospective cohort study
Fronczek J, Polok K, de Lange DW, Jung C, Beil M, Rhodes A, Fjølner J, Górka
J, Andersen FH, Artigas A, Cecconi M, Christensen S, Joannidis M, Leaver S,
Marsh B, Morandi A, Moreno R, Oeyen S, Agvald-Öhman C, Bollen Pinto B, Schefold
JC, Valentin A, Walther S, Watson X, Zafeiridis T, Sviri S, van Heerden PV,
Flaatten H, Guidet B, Szczeklik W; VIP1; VIP2 study group
Steroid use in elderly critically ill COVID-19 patients
Jung C, Wernly B, Fjølner J, Bruno RR, Dudzinski D, Artigas A, Pinto BB,
Schefold JC, Wolff G, Kelm M, Beil M, Sigal S, van Heerden PV, Szczeklik W,
Czuczwar M, Elhadi M, Joannidis M, Oeyen S, Zafeiridis T, Marsh B, Andersen FH,
Moreno R, Cecconi M, Leaver S, Boumendil A, De Lange DW, Guidet B, Flaatten H;
COVIP study group
Provision of critical care for the elderly in Europe: a retrospective comparison of national healthcare frameworks in intensive care units
Wernly B, Beil M, Bruno RR, Binnebössel S, Kelm M, Sigal S, van Heerden PV,
Boumendil A, Artigas A, Cecconi M, Marsh B, Moreno R, Oeyen S, Bollen Pinto B,
Szczeklik W, Leaver S, Walther SM, Schefold JC, Joannidis M, Fjølner J,
Zafeiridis T, de Lange D, Guidet B, Flaatten H, Jung C; VIP2 study group
Frailty and survival in elderly intensive care patients in Norway
Andersen FH, Ariansen Haaland Ø, Klepstad P, Flaatten H
The impact of frailty on survival in elderly intensive care patients with COVID-19: the COVIP study
Jung C, Flaatten H, Fjølner J, Bruno RR, Wernly B, Artigas A, Bollen Pinto B,
Schefold JC, Wolff G, Kelm M, Beil M, Sviri S, van Heerden PV, Szczeklik W,
Czuczwar M, Elhadi M, Joannidis M, Oeyen S, Zafeiridis T, Marsh B, Andersen FH,
Moreno R, Cecconi M, Leaver S, Boumendil A, De Lange DW, Guidet B; COVIP study
group.
Frailty is associated with long-term outcome in patients with sepsis who are over 80 years old: results from an observational study in 241 European ICUs
Haas LEM, Boumendil A, Flaatten H, Guidet B, Ibarz M, Jung C, Moreno R,
Morandi A, Andersen FH, Zafeiridis T, Walther S, Oeyen S, Leaver S, Watson X,
Boulanger C, Szczeklik W, Schefold JC, Cecconi M, Marsh B, Joannidis M, Nalapko
Y, Elhadi M, Fjølner J, Artigas A, de Lange DW; VIP2 study group
Age and ageing. 2021-03-23PubmedVIP2
Reliability of the Clinical Frailty Scale in very elderly ICU patients: a prospective European study
Flaatten H, Guidet B, Andersen FH, Artigas A, Cecconi M, Boumendil A, Elhadi
M, Fjølner J, Joannidis M, Jung C, Leaver S, Marsh B, Moreno R, Oeyen S, Nalapko
Y, Schefold JC, Szczeklik W, Walther S, Watson X, Zafeiridis T, de Lange DW
Frailty as a Prognostic Indicator in Intensive Care
Jung C, Bruno RR, Wernly B, Wolff G, Beil M, Kelm M
Deutsches Ärzteblatt international. 2021-01-04;117;668-673PubmedFree full text link
Disease-course adapting machine learning prognostication models in critically ill elderly COVID-19 patients: a multi-centre cohort study with external validation
Jung C, Mamandipoor B, Fjølner J, Bruno R, Wernly B, Artigas A, Bollen Pinto
B, Schefold JC, Wolff G, Kelm M, Beil M, Sviri S, van Heerden PV, Szczeklik W,
Czuczwar M, Elhadi M, Joannidis M, Oeyen S, Zafeiridis T, Marsh B, Andersen FH,
Moreno R, Cecconi M, Leaver S, De Lange DW, Guidet B, Flaatten H, Osmani V
Sex-specific outcome disparities in very old patients admitted to intensive care medicine: a propensity matched analysis
Wernly B, Bruno RR, Kelm M, Boumendil A, Morandi A, Andersen FH, Artigas A,
Finazzi S, Cecconi M, Christensen S, Faraldi L, Lichtenauer M, Muessig JM, Marsh
B, Moreno R, Oeyen S, Öhman CA, Pinto BB, Soliman IW, Szczeklik W, Niederseer D,
Valentin A, Watson X, Leaver S, Boulanger C, Walther S, Schefold JC, Joannidis
M, Nalapko Y, Elhadi M, Fjølner J, Zafeiridis T, De Lange DW, Guidet B, Flaatten
H, Jung C; VIP2 Study Group.
The wave of very old people in the intensive care unit-A challenge in decision-making
van Heerden PV, Sviri S, Beil M, Szczeklik W, de Lange D, Jung C, Guidet B,
Leaver S, Rhodes A, Boumendil A, Flaatten H
J Crit Care. 2020-09-10;Sep 10;290-293Pubmed
Prognostication in older ICU patients: mission impossible?
Flaatten H, Beil M, Guidet B
Br J Anaesth. 2020-08-14;125;655-657PubmedFree full text link
Therapy limitation in octogenarians in German intensive care units is associated with a longer length of stay and increased 30 days mortality: A prospective multicenter study
Bruno RR, Wernly B, Beil M, Muessig JM, Rahmel T, Graf T, Meybohm P, Schaller
SJ, Allgäuer S, Franz M, Westphal JG, Barth E, Ebelt H, Fuest K, Horacek M,
Schuster M, Dubler S, Schering S, Wolff G, Steiner S, Rabe C, Dieck T, Lauten A,
Sacher AL, Brenner T, Bloos F, Jánosi RA, Simon P, Utzolino S, Kelm M, De Lange
DW, Guidet B, Flaatten H, Jung C
Elderly Patients in the Intensive Care Unit
Flaatten H, Beil M, Guidet B
Semin Respir Crit Care Med. 2020-08-01;17(01)Pubmed
Comments to "Frailty is associated with hospital readmission in geriatric patients: a prognostic study" : Assessment of frailty in geriatric patients: let's keep it simple
Bruno RR, Wernly B, Guidet B, Flaatten H, De Lange DW, Jung C
Eur Geriatr Med. 2020-07-18;Jul18Pubmed
Inhibitors of the Renin-Angiotensin-Aldosterone System and Covid-19 in critically ill elderly patients
Jung C, Bruno RR, Wernly B, Joannidis M, Oeyen S, Zafeiridis T, Marsh B,
Andersen FH, Moreno R, Fernandes AM, Artigas A, Pinto BB, Schefold J, Wolff G,
Kelm M, De Lange DW, Guidet B, Flaatten H, Fjølner J
European heart journal. Cardiovascular pharmacotherapy. 2020-07-09;Jul 9PubmedCOVIP
Frailty assessment in very old intensive care patients: the Hospital Frailty Risk Score answers another question
Bruno RR, Guidet B, Wernly B, Flaatten H, Jung C
Intensive Care Med. 2020-07-01;46;4847-1515PubmedFree full text link
The good, the bad and the ugly: pandemic priority decisions and triage
Flaatten H, Van Heerden V, Jung C, Beil M, Leaver S, Rhodes A, Guidet B,
deLange DW
Journal of Medical Ethics. 2020-06-10PubmedFree full text link
Sepsis at ICU Admission Does Not Decrease 30-day Survival in Very Old Patients: A Post-Hoc Analysis of the VIP1 Multinational Cohort Study
Ibarz M, Boumendil A, Haas LEM, Irazabal M, Flaatten H, de Lange DW, Morandi
A, Andersen FH, Bertolini G, Cecconi M, Christensen S, Faraldi L, Fjølner J,
Jung C, Marsh B, Moreno R, Oeyen S, Öhman CA, Bollen Pinto B, Soliman IW,
Szczeklik W, Valentin A, Watson X, Zaferidis T, Guidet B, Artigas A; VIP1 study
Annals of intensive care. 2020-05-13;10PubmedVIP1
The contribution of frailty, cognition, activity of daily life and comorbidities on outcome in acutely admitted patients over 80 years in European ICUs: the VIP2 study. Intensive care medicine
Guidet B, de Lange DW, Boumendil A, Leaver S, Watson X, Boulanger C, Szczeklik W, Artigas A, Morandi A, Andersen F), Zafeiridis T), Jung C), Moreno R), Walther S, Oeyen S, Schefold JC, Cecconi M, Marsh B, Joannidis M, Nalapko Y, Elhadi M, Fjølner J, Flaatten H; VIP2 study group.
Validation of the clinical frailty score (CFS) in French language
Abraham P, Courvoisier DS, Annweiler C, Lenoir C, Millien T, Dalmaz F,
Flaatten H, Moreno R, Christensen S, de Lange DW, Guidet B, Bendjelid K, Walder
B, Bollen Pinto B
BMC Geriatr. 2019-11-21;19;322PubmedFree full text link
Frailty increases mortality among patients ≥80 years old treated in Polish ICUs
Fronczek J, Polok KJ, Nowak-Kózka I, Włudarczyk A, Górka J, Czuczwar M,
Krawczyk P, Ziętkiewicz M, Nowak ŁR, Żukowski M, Kotfis K, Cwyl K, Gajdosz R,
Bohatyrewicz R, Biernawska J, Grudzień P, Nasiłowski P, Popek N, Cyrankiewicz W,
Wawrzyniak K, Wnuk M, Maciejewski D, Studzińska D, Bernas S, Piechota M, Machała
W, Serwa M, Wujtewicz M, Stefaniak J, Szymkowiak M, Gawda R, Adamik B, Kozera N,
Goździk W, Flaatten H, Szczeklik W
The hospital frailty risk score is of limited value in intensive care unit patients
Bruno RR, Wernly B, Flaatten H, Schölzel F, Kelm M, Jung C
Critical Care. 2019-07-02;23;239PubmedFree full text link
Huge variation in obtaining ethical permission for a non-interventional observational study in Europe
de Lange DW, Guidet B, Andersen FH, Artigas A, Bertolini G, Moreno R, Christensen S, Cecconi M, Agvald-Ohman C, Gradisek P, Jung C, Marsh BJ, Oeyen S, Bollen Pinto B, Szczeklik W, Watson X, Zafeiridis T, Flaatten H
A comparison of very old patients admitted to intensive care unit after acute versus elective surgery or intervention
Jung C, Wernly B, Muessig JM, Kelm M, Boumendil A, Morandi A, Andersen FH,
Artigas A, Bertolini G, Cecconi M, Christensen S, Faraldi L, Fjølner J,
Lichtenauer M, Bruno RR, Marsh B, Moreno R, Oeyen S, Öhman CA, Pinto BB, Soliman
IW, Szczeklik W, Valentin A, Watson X, Zafeiridis T, De Lange DW, Guidet B,
Flaatten H; VIP1 study group
J Crit Care. 2019-05-02;52;141-148PubmedVIP1
Cumulative Prognostic Score Predicting Mortality in Patients Older Than 80 Years Admitted to the ICU
de Lange DW, Brinkman S, Flaatten H, Boumendil A, Morandi A, Andersen FH, Artigas A, Bertolini G, Cecconi M, Christensen S, Faraldi L, Fjølner J, Jung C, Marsh B, Moreno R, Oeyen S, Öhman CA, Bollen Pinto B, de Smet AMGA, Soliman IW, Szczeklik W, Valentin A, Watson X, Zafeiridis T, Guidet B; VIP1 Study Group
Journal of the American Geriatrics Society. 2019-04-12;67;1263-1267PubmedVIP1
How Does Frailty Affect ICU Outcome?
Hans Flaatten, Christian Jung, Helene Vallet, Bertrand Guidet
Current Anesthesiology Reports . 2019-04-01;144-150
Caring for the Critically Ill Patients over 80: A Narrative Review
Guidet Bertrand, Helene Vallet, Jacques Boddaert, Dylan W. de Lange, Alessandro Morandi, Guillaume Leblanc, Antonio Artigas, and Hans Flaatten
Annals of Intensive Care. 2018-11-26PubmedFree full text link
Frailty: We need valid and reliable tools in critical care
Flaatten H, Clegg A
Intensive Care Medicine. 2018-11-01;44;1973‐1975Pubmed
Frailty Is Associated With an Increased Mortality Among Patients ≥ 80 Years Old Treated in Polish ICUs
Jakub Fronczek, Kamil Jurand Polok, Ilona Nowak-Kózka, Anna Włudarczyk, Jacek Górka, Mirosław Czuczwar, Paweł Krawczyk, Mirosław Ziętkiewicz, Łukasz R Nowak, Maciej Żukowski, Katarzyna Kotfis, Katarzyna Cwyl, Ryszard Gajdosz, Romuald Bohatyrewicz, Jowita Biernawska, Paweł Grudzień, Paweł Nasiłowski, Natalia Popek, Waldemar Cyrankiewicz, Katarzyna Wawrzyniak, Marek Wnuk, Dariusz Maciejewski, Dorota Studzińska, Szymon Bernas, Mariusz Piechota, Waldemar Machała, Marta Serwa, Maria Wujtewicz, Jan Stefaniak, Małgorzata Szymkowiak, Ryszard Gawda, Barbara Adamik, Natalia Kozera, Waldemar Goździk, Hans Flaatten, Wojciech Szczeklik
Anaesthesiology intensive therapy / Anestezjologia intensywna terapia . 2018-09-22;50;245-251PubmedVIP1
Clinical Frailty Scale (CFS) reliably stratifies octogenarians in German ICUs: a multicentre prospective cohort study
Muessig JM, Nia AM, Masyuk M, Lauten A, Sacher AL, Brenner T, Franz M, Bloos F, Ebelt H, Schaller SJ, Fuest K, Rabe C, Dieck T, Steiner S, Graf T, Jánosi RA, Meybohm P, Simon P, Utzolino S, Rahmel T, Barth E, Schuster M, Kelm M, Jung C.
Predicting outcomes in very old ICU patients: time to focus on the past?
Flaatten H, Oeyen S, deLange DW
Intensive Care Medicine. 2018-07-02;44;1344-1345Pubmed
Withholding or withdrawing of life-sustaining therapy in older adults (≥ 80 years) admitted to the intensive care unit
Guidet B, Flaatten H, Boumendil A, Morandi A, Andersen FH, Artigas A,
Bertolini G, Cecconi M, Christensen S, Faraldi L, Fjølner J, Jung C, Marsh B, Moreno R, Oeyen S, Öhman CA, Pinto BB, Soliman IW, Szczeklik W, Valentin A, Watson X, Zafeiridis T, De Lange DW; VIP1 study group
Should this elderly patient be admitted to the ICU?
Guidet B, de Lange DW, Flaatten H
Intensive Care Medicine. 2018-01-22;44;1926-1928Pubmed
The impact of frailty on ICU and 30-day mortality and the level of care in very elderly patients (≥ 80 years)
Flaatten H, De Lange DW, Morandi A, Andersen FH, Artigas A, Bertolini G, Boumendil A, Cecconi M, Christensen S, Faraldi L, Fjølner J, Jung C, Marsh B, Moreno R, Oeyen S, Öhman CA, Pinto BB, Soliman IW, Szczeklik W, Valentin A, Watson X, Zaferidis T, Guidet B; VIP1 study group
Intensive Care Medicine. 2017-09-21;43;1820-1828PubmedVIP1
The Status of Intensive Care Medicine Research and a Future Agenda for Very Old Patients in the ICU
Moreno R, Christensen S, Joynt GM,
Bagshaw SM, Sprung CL, Benoit D, Soares M, Guidet B
Intensive Care Medicine. 2017-09-01;43;1319-1328Pubmed