VIP papers

The (un)surprising resilience of octogenarians in intensive care

Beil M, Jacobs JM, Guidet B

Intensive Care Medicine. 2025-01-07

The role of artificial intelligence in life- sustaining treatment decisions: current state and future considerations

Wernly B, Guidet B, Beil M

Intensive Care Medicine. 2025-01-01;157-159

Contemporary assessment of short- and functional 90-days outcome in old intensive care patients suffering from COVID-19

Bruno RR, Wernly B, Artigas A, Fuest K, Schaller SJ, Dannenberg L, Kindgen- Milles D, Kelm M, Beil M, Sviri S, Elhadi M, Joannidis M, Oeyen S, Kondili E, Moreno R, Leaver S, Guidet B, De Lange DW, Flaatten H, Szczeklik W, Jung C

Journal of Critical Care. 2024-12-03;86

Prognosticating the outcome of intensive care in older patients-a narrative review

Beil M, Moreno R, Fronczek J, Kogan Y, Moreno RPJ, Flaatten H, Guidet B, de Lange D, Leaver S, Nachshon A, van Heerden PV, Joskowicz L, Sviri S, Jung C, Szczeklik W

Annals of Intensive Care. 2024-06-22;14

Critical care beyond organ support: the importance of geriatric rehabilitation

Jacobs JM, Rahamim A, Beil M, Guidet B, Vallet H, Flaatten H, Leaver SK, de Lange D, Szczeklik W, Jung C, Sviri S

Annals of Intensive Care. 2024-05-10;14

The association of premorbid conditions with 6-month mortality in acutely admitted ICU patients over 80 years

e Lange DW, Soliman IW, Leaver S, Boumendil A, Haas LEM, Watson X, Boulanger C, Szczeklik W, Artigas A, Morandi A, Andersen F, Jung C, Moreno R, Walther S, Oeyen S, Schefold JC, Cecconi M, Marsh B, Joannidis M, Nalapko Y, Elhadi M, Fjølner J, Guidet B, Flaatten H

Annals of Intensive Care. 2024-03-30;14

30-day mortality among very old patients admitted to European intensive care units for major trauma

Duncan CF, Lonsdale DO, Farrah H, Farnell-Ward S, Ryan C, Watson X, Cecconi M, Fjølner J, Szczeklik W, Moreno R, Artigas A, Joannidis M, De Lange DW, Guidet B, Flaatten H, Jung C, Leaver S

Gerontology. . 2024-02-22

PubmedVIP1VIP2

Prevalence of life-sustaining treatment limitations in Polish very old intensive care patients (VIPs). A ost-hoc analysis of two prospective observational studies

Pasieka P, Surówka A, Fronczek J, Skwara E, Czuczwar M, Borys M, Krawczyk P, Ziętkiewicz M, Nowak ŁR, Żukowski M, Kotfis K, Cwyl K, Skowronek J, Solek- Pastuszka J, Biernawska J, Grudzień P, Nasiłowski P, Popek N, Cyrankiewicz W, Sierakowska K, Mudyna W, Białka S, Studzińska D, Bernas S, Piechota M, Machała W, Sadowski Ł, Stefaniak J, Owczuk R, Szymkowiak M, Gawda R, Kozera N, Adamik B, Goździk W, Wieczorek A, Janc J, Kluzik A, rzebicki J, Zatorski P, Gola W, Hymczak H, Krzych LJ, Czajka S, Kościuczuk U, Kudliński B, Flaatten H, Szczeklik W

J Crit Care. 2024-02-01;79

Predictors of outcomes of patients ≥ 80 years old admitted to intensive care units in Poland - a post-hoc analysis of the VIP2 prospective observational study

Pasieka PM, Kurek M, Skupnik W, Skwara E, Bezshapkin V, Fronczek J, Kluzik A, Kudliński B, Białka S, Studzińska D, Krzych Ł, Czajka S, Stefaniak J, Owczuk R, Sołek-Pastuszka J, Biernawska J, Zorska J, Krawczyk P, Cwyl K, Żukowski M, Kotfis K, Zegan-Barańska M, Wieczorek A, Mudyna W, Piechota M, Bernas S, Machała W, Sadowski Ł, Serwa M, Czuczwar M, Borys M, Ziętkiewicz M, Kozera N, Adamik B, Goździk W, Nasiłowski P, Zatorski P, Trzebicki J, Gałkin P, Gawda R, Kościuczuk U, Cyrankiewicz W, Sierakowska K, Gola W, Hymczak H, Flaatten H, zczeklik W

Anaesthesiol Intensive Ther. 2024-01-24;56

The trajectory of very old critically ill patients

Guidet B, Vallet H, Flaatten H, Joynt G, Bagshaw SM, Leaver SK, Beil M, Du B, Forte DN, Angus DC, Sviri S, de Lange D, Herridge MS, Jung C

Intensive Care Med. 2024-01-18

Odds Ratios vs. Risk Ratios in Intensive Care Research: Using Frailty in Intensive Care as a Case Study

Wernly B, Beil M, Guidet B, Flaaten H, Jung C

Academic Emergency Medicine. 2023-12-23

Frailty's influence on 30-day mortality in old critically ill ICU patients: a bayesian analysis evaluating the clinical frailty scale

Wernly B, Bruno RR, Beil M, Flaatten H, Kelm M, Sigal S, Szczeklik W, Elhadi M, Joannidis M, Koköfer A, Oeyen S, Marsh B, Moreno R, Wernly S, Leaver S, De Lange DW, Guidet B, Jung C

Annals of Intensive Care. 2023-12-13;13

PubmedVIP1VIP2COVIP

Reporting SOFA in research: we should always present each of the SOFA subscores

Putowski Z, Czok M, Polok K, Guidet B, Jung C, Bruno RR, de Lange D, Leaver S, Moreno R, Wernly B, Flaatten H, Szczeklik W

Anaesthesiology Intensive Therapy. 2023-11-13;55

Pubmed Free full text linkVIP2COVIP

Limiting life-sustaining treatment for very old ICU patients: cultural challenges and diverse practices

Beil M, van Heerden PV, Joynt GM, Lapinsky S, Flaatten H, Guidet B, de Lange D, Leaver S, Jung C, Forte DN, Bin D, Elhadi M, Szczeklik W, Sviri S

Annals of Intensive Care. 2023-10-27;13

Validity of the total SOFA score in patients ≥ 80 years old acutely admitted to intensive care units: a post-hoc analysis of the VIP2 prospective, international cohort study

Polok K, Fronczek J, Putowski Z, Czok M, Guidet B, Jung C, de Lange D, Leaver S, Moreno R, Flatten H, Szczeklik W

Annals of Intensive Care. 2023-10-05;13

Mortality in older patients admitted to an ICU for COVID-19: A systematic review

Bianco C, Guidet B, Flaatten H, Dechartres A, Vallet H

Acta Anaesthesiologica Scandinavica. 2023-09-23;67;1140-1147

The impact of age-related syndromes on ICU process and outcomes in very old patients

Vallet H, Guidet B, Boumendil A, De Lange DW, Leaver S, Szczeklik W, Jung C, Sviri S, Beil M, Flaatten H

Annals of Intensive Care. 2023-08-23;13

Improving frailty assessment: the task is not finished

Wernly B, Flaatten H, Leaver S, Guidet B, Jung C; COVIP investigators

Critical Care. 2023-06-01;27;218

Associations of anemia and blood transfusions with mortality in old, critically ill COVID-19 patients - Results from the prospective COVIP Study

Erkens R, Duse D, Wernly B, Flaatten H, Fjølner J, Bruno RR, Wolff G, Artigas A, Kelm M, Beil M, Sviri S, Schaller SJ, Fuest K, Szczeklik W, Piayda K, Elhadi M, Joannidis M, Nedergaard HK, Oeyen S, Moreno R, Leaver S, de Lange DW, Guidet B, Jung C; COVIP study group

Clinical Hemorheology and Microcirculation. 2023-05-22

PubmedCOVIP

The role of clinical phenotypes in decisions to limit life-sustaining treatment for very old patients in the ICU

Mousai O, Tafoureau L, Yovell T, Flaatten H, Guidet B, Beil M, de Lange D, Leaver S, Szczeklik W, Fjolner J, Nachshon A, van Heerden PV, Joskowicz L, Jung C, Hyams G, Sviri S

Annals of Intensive Care. 2023-05-10;13(1)

The Clinical Frailty Scale for mortality prediction of old acutely admitted intensive care patients: a meta-analysis of individual patient-level data

Bruno RR, Wernly B, Bagshaw SM, van den Boogaard M, Darvall JN, De Geer L, de Gopegui Miguelena PR, Heyland DK, Hewitt D, Hope AA, Langlais E, Le Maguet P, Montgomery CL, Papageorgiou D, Seguin P, Geense WW, Silva-Obregón JA, Wolff G, Polzin A, Dannenberg L, Kelm M, Flaatten H, Beil M, Franz M, Sviri S, Leaver S, Guidet B, Boumendil A, Jung C

Annals of Intensive Care. 2023-05-03;13

The clinical frailty scale, but not the FRAIL checklist is associated with mortality in old critically ill patients with COVID-19

Wernly B, Flaatten H, Leaver S, Guidet B, Jung C; COVIP investigators

Critical Care. 2023-03-10;27

Diabetes mellitus is associated with 90-day mortality in old critically ill COVID-19 patients: a multicenter prospective observational cohort study

Mayerhöfer T, Klein S, Wernly B, Flaatten H, Guidet B, De Lange DW, Fjølner J, Leaver S, Beil M, Sviri S, Bruno RR, Artigas A, van Heerden PV, Pinto BB, Schefold JC, Moreno R, Cecconi M, Szczeklik W, Jung C, Joannidis M; COVIP study group

Infection. 2023-03-01;1-9

Contribution of information about acute and geriatric characteristics to decisions about life-sustaining treatment for old patients in intensive care

Beil M, van Heerden PV, de Lange DW, Szczeklik W, Leaver S, Guidet B, Flaatten H, Jung C, Sviri S, Joskowicz L

BMC Medical Informatics and Decision Making. 2023-01-06

The association of prior paracetamol intake with outcome of very old intensive care patients with COVID-19: results from an international prospective multicentre trial

Baldia PH, Wernly B, Flaatten H, Fjølner J, Artigas A, Pinto BB, Schefold JC, Kelm M, Beil M, Bruno RR, Binnebößel S, Wolff G, Erkens R, Sigal S, van Heerden PV, Szczeklik W, Elhadi M, Joannidis M, Oeyen S, Marsh B, Andersen FH, Moreno R, Leaver S, De Lange DW, Guidet B, Jung C; COVIP study group

BMC Geriatrics. 2022-12-27;22

COVID-19 machine learning model predicts outcomes in older patients from various European countries, between pandemic waves, and in a cohort of Asian, African, and American patients

Mamandipoor B, Bruno RR, Wernly B, Wolff G, Fjølner J, Artigas A, Pinto BB, Schefold JC, Kelm M, Beil M, Sigal S, Leaver S, De Lange DW, Guidet B, Flaatten H, Szczeklik W, Jung C, Osmani V

PLOS Digit Health. 2022-11-08

Consent is a confounding factor in a prospective observational study of critically ill elderly patients

Flaatten H, Guidet B, Jung C, Boumendil A, Leaver S, Szczeklik W, Artigas A, Andersen F, Moreno R, Walther S, Oeyen S, Schefold JC, Marsh B, Joannidis M, Elhadi M, Nalapko Y, Fjølner J, de Lange DW

PLoS One. 2022-10-27

A retrospective cohort study comparing differences in 30-day mortality among critically ill patients aged ≥ 70 years treated in European tax-based healthcare systems (THS) versus social health insurance systems

Wernly B, Flaatten H, Beil M, Fjølner J, Bruno RR, Artigas A, Pinto BB, Schefold JC, Kelm M, Sigal S, van Heerden PV, Szczeklik W, Elhadi M, Joannidis M, Rezar R, Oeyen S, Wolff G, Marsh B, Andersen FH, Moreno R, Wernly S, Leaver S, Boumendil A, De Lange DW, Guidet B, Perings S, Jung C

Scientific Reports. 2022-10-19;12

Cytokine absorption in critically ill old COVID-19 patients with renal failure: A retrospective analysis of 503 intensive care unit patients

Binneboessel S, Bruno RR, Wernly B, Masyuk M, Flaatten H, Fjølner J, Wolff G, Kelm M, Beil M, Sviri S, Szczeklik W, Leaver S, De Lange DW, Guidet B, Jung C; COVIP study group

Clinical Hemorheology and Microcirculation. 2022-10-15

Frailty in intensive care medicine must be measured, interpreted and taken into account!

Jung C, Guidet B, Flaatten H; VIP study group

Intensive Care Medicine. 2022-10-07

Clustering analysis of geriatric and acute characteristics in a cohort of very old patients on admission to ICU

Mousai O, Tafoureau L, Yovell T, Flaatten H, Guidet B, Jung C, de Lange D, Leaver S, Szczeklik W, Fjolner J, van Heerden PV, Joskowicz L, Beil M, Hyams G, Sviri S

Intensive Care Medicine. 2022-09-02

PubmedVIP2

Sex-specific treatment characteristics and 30-day mortality outcomes of critically ill COVID-19 patients over 70 years of age-results from the prospective COVIP study

Wolff G, Wernly B, Flaatten H, Fjølner J, Bruno RR, Artigas A, Pinto BB, Schefold JC, Kelm M, Binneboessel S, Baldia P, Beil M, Sivri S, van Heerden PV, Szczeklik W, Elhadi M, Joannidis M, Oeyen S, Flamm M, Zafeiridis T, Marsh B, Andersen FH, Moreno R, Boumendil A, De Lange DW, Guidet B, Leaver S, Jung C; COVIP Study Group

Canadian Journal of Anaesthesia. 2022-08-09

Noninvasive ventilation in COVID-19 patients aged ≥ 70 years-a prospective multicentre cohort study

Polok K, Fronczek J, Artigas A, Flaatten H, Guidet B, De Lange DW, Fjølner J, Leaver S, Beil M, Sviri S, Bruno RR, Wernly B, Bollen Pinto B, Schefold JC, Studzińska D, Joannidis M, Oeyen S, Marsh B, Andersen FH, Moreno R, Cecconi M, Jung C, Szczeklik W

Critical Care. 2022-07-22;26

Who gets the ventilator? A multicentre survey of intensivists' opinions of triage during the first wave of the COVID-19 pandemic

Fjølner J, Haaland ØA, Jung C, de Lange DW, Szczeklik W, Leaver S, Guidet B, Sviri S, Van Heerden PV, Beil M, Hartog CS, Flaatten H

Acta Anaesthesiologica Scandinavica. 2022-06-09

Time-dependent uncertainty of critical care transitions in very old patients - lessons for time-limited trials

Michael Beil, Hans Flaatten, Bertrand Guidet, Leo Joskowicz, Christian Jung, Dylan de Lange, Susannah Leaver, Jesper Fjølner, Wojciech Szczeklik, Sigal Sviri, Peter Vernon van Heerden

Journal of Critical Care. 2022-05-30;71

PubmedVIP2

Short-term mortality of patients ≥80 years old admitted to European intensive care units: an international observational study

Fronczek J, Flaatten H, Guidet B, Polok K, Andersen FH, Andrew BY, Artigas A, Beil M, Cecconi M, Christensen S, de Lange DW, Fjølner J, Górka J, Joannidis M, Jung C, Kusza K, Leaver S, Marsh B, Morandi A, Moreno R, Oeyen S, Owczuk R, Agvald-Öhman C, Pinto BB, Rhodes A, Schefold JC, Soliman IW, Valentin A, Walther S, Watson X, Zafeiridis T, Szczeklik W; VIP1 & VIP2 study group

British Journal of Anaesthesia. 2022-04-29

PubmedVIP1VIP2

Variations in end-of-life care practices in older critically ill patients with COVID-19 in Europe

Wernly B, Rezar R, Flaatten H, Beil M, Fjølner J, Bruno RR, Artigas A, Pinto BB, Schefold JC, Kelm M, Sigal S, van Heerden PV, Szczeklik W, Elhadi M, Joannidis M, Oeyen S, Wolff G, Marsh B, Andersen FH, Moreno R, Leaver S, Wernly S, Boumendil A, De Lange DW, Guidet B, Jung C

Journale of Internal Medicine. 2022-04-05

Association of chronic heart failure with mortality in old intensive care patients suffering from Covid-19

Bruno RR, Wernly B, Wolff G, Fjølner J, Artigas A, Bollen Pinto B, Schefold JC, Kindgen-Milles D, Baldia PH, Kelm M, Beil M, Sviri S, van Heerden PV, Szczeklik W, Topeli A, Elhadi M, Joannidis M, Oeyen S, Kondili E, Marsh B, Andersen FH, Moreno R, Leaver S, Boumendil A, De Lange DW, Guidet B, Flaatten H, Jung C; COVIP study group

ESC Heart Failure. 2022-03-19

The association of the Activities of Daily Living and the outcome of old intensive care patients suffering from COVID-19

Bruno RR, Wernly B, Flaatten H, Fjølner J, Artigas A, Baldia PH, Binneboessel S, Bollen Pinto B, Schefold JC, Wolff G, Kelm M, Beil M, Sviri S, van Heerden PV, Szczeklik W, Elhadi M, Joannidis M, Oeyen S, Kondili E, Marsh B, Wollborn J, Andersen FH, Moreno R, Leaver S, Boumendil A, De Lange DW, Guidet B, Jung C; COVIP study group

Annals of Intensive Care. 2022-03-18;12

PubmedCOVIP

Increased 30-day mortality in very old ICU patients with COVID-19 compared to patients with respiratory failure without COVID-19

Guidet B, Jung C, Flaatten H, Fjølner J, Artigas A, Pinto BB, Schefold JC, Beil M, Sigal S, van Heerden PV, Szczeklik W, Joannidis M, Oeyen S, Kondili E, Marsh B, Andersen FH, Moreno R, Cecconi M, Leaver S, De Lange DW, Boumendil A; VIP2 and COVIP study groups

Intensive Care Medicine. 2022-02-26;Feb

Pubmed Free full text linkVIP2COVIP

Health-related quality of life in older patients surviving ICU treatment for COVID-19: results from an international observational study of patients older than 70 years

Soliman IW, Leaver S, Flaatten H, Fjølner J, Wernly B, Bruno RR, Artigas A, Bollen Pinto B, Schefold JC, Beil M, Sviri S, van Heerden PV, Szczeklik W, Elhadi M, Joannidis M, Oeyen S, Zafeiridis T, Wollborn J, Banzo MJA, Fuest K, Marsh B, Andersen FH, Moreno R, Boumendil A, Guidet B, Jung C, De Lange DW; COVIP-study group

Age and Ageing. 2022-02-10

The clinical frailty scale - does it predict outcome of the very-old in UK ICUs?

Dagan O Lonsdale, Liting Tong, Helen Farrah, Sarah Farnell-Ward, Chris Ryan, Ximena Watson, Maurizio Cecconi, Hans Flaatten, Jesper Fjølner, Christian Jung, Bertrand Guidet, Dylan de Lange, Wojciech Szczeklik, Johanna M Muessig, Susannah K Leaver

Journal of the Intensive Care Society. 2022-02-09

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Association between tracheostomy timing and outcomes for older critically ill COVID-19 patients: prospective observational study in European intensive care units

Polok K, Fronczek J, van Heerden PV, Flaatten H, Guidet B, De Lange DW, Fjølner J, Leaver S, Beil M, Sviri S, Bruno RR, Wernly B, Artigas A, Pinto BB, Schefold JC, Studzińska D, Joannidis M, Oeyen S, Marsh B, Andersen FH, Moreno R, Cecconi M, Jung C, Szczeklik W; COVIP study group

British Journal of Anaesthesia. 2021-11-29

The importance of revealing data on limitation of life sustaining therapy in critical ill elderly Covid-19 patients

Flaatten H, Guidet B, de Lange DW, Beil M, Leaver SK, Fjølner J, van Heerden PV, Sigal S, Szczeklik W, Jung C

Journal of Critical Care. 2021-11-15;67;147-148

Management and outcomes in critically ill nonagenarian versus octogenarian patients

Bruno RR, Wernly B, Kelm M, Boumendil A, Morandi A, Andersen FH, Artigas A, Finazzi S, Cecconi M, Christensen S, Faraldi L, Lichtenauer M, Muessig JM, Marsh B, Moreno R, Oeyen S, Öhman CA, Pinto BB, Soliman IW, Szczeklik W, Valentin A, Watson X, Leaver S, Boulanger C, Walther S, Schefold JC, Joannidis M, Nalapko Y, Elhadi M, Fjølner J, Zafeiridis T, De Lange DW, Guidet B, Flaatten H, Jung C; VIP2 study group

BMC Geriatrics. 2021-10-19;21

Differences in mortality in critically ill elderly patients during the second COVID-19 surge in Europe

Jung C, Fjølner J, Bruno RR, Wernly B, Artigas A, Bollen Pinto B, Schefold JC, Wolff G, Kelm M, Beil M, Sviri S, van Heerden PV, Szczeklik W, Czuczwar M, Joannidis M, Oeyen S, Zafeiridis T, Andersen FH, Moreno R, Leaver S, Boumendil A, De Lange DW, Guidet B, Flaatten H; , COVIP Study Group

Critical Care. 2021-09-23;25

The management of multi-morbidity in elderly patients: Ready yet for precision medicine in intensive care?

Beil M, Flaatten H, Guidet B, Sviri S, Jung C, de Lange D, Leaver S, Fjølner J, Szczeklik W, van Heerden PV

Critical Care. 2021-09-10

Early evaluation of organ failure using MELD-XI in critically ill elderly COVID-19 patients

Bruno RR, Wernly B, Hornemann J, Flaatten H, FjØlner J, Artigas A, Bollen Pinto B, Schefold JC, Wolff G, Baldia PH, Binneboessel S, Kelm M, Beil M, Sviri S, van Heerden PV, Szczeklik W, Elhadi M, Joannidis M, Oeyen S, Kondili E, Wollborn J, Marsh B, Andersen FH, Moreno R, Leaver S, Boumendil A, De Lange DW, Guidet B, Jung C; COVIP study group

Clin Hemorheol Microcirc. 2021-08-28

PubmedCOVIP

Lactate is associated with mortality in very old intensive care patients suffering from COVID-19: results from an international observational study of 2860 patients

Bruno RR, Wernly B, Flaatten H, Fjølner J, Artigas A, Bollen Pinto B, Schefold JC, Binnebössel S, Baldia PH, Kelm M, Beil M, Sigal S, van Heerden PV, Szczeklik W, Elhadi M, Joannidis M, Oeyen S, Zafeiridis T, Wollborn J, Arche Banzo MJ, Fuest K, Marsh B, Andersen FH, Moreno R, Leaver S, Boumendil A, De Lange DW, Guidet B, Jung C; COVIP Study Group

Annals of Intensive Care. 2021-08-21

PubmedCOVIP

ICU-Mortality in Old and Very Old Patients Suffering From Sepsis and Septic Shock

Bruno RR, Wernly B, Mamandipoor B, Rezar R, Binnebössel S, Baldia PH, Wolff G, Kelm M, Guidet B, De Lange DW, Dankl D, Koköfer A, Danninger T, Szczeklik W, Sigal S, van Heerden PV, Beil M, Fjølner J, Leaver S, Flaatten H, Osmani V, Jung C

Frontiers of Medicine. 2021-07-09

Relationship between the Clinical Frailty Scale and short-term mortality in patients ≥ 80 years old acutely admitted to the ICU: a prospective cohort study

Fronczek J, Polok K, de Lange DW, Jung C, Beil M, Rhodes A, Fjølner J, Górka J, Andersen FH, Artigas A, Cecconi M, Christensen S, Joannidis M, Leaver S, Marsh B, Morandi A, Moreno R, Oeyen S, Agvald-Öhman C, Bollen Pinto B, Schefold JC, Valentin A, Walther S, Watson X, Zafeiridis T, Sviri S, van Heerden PV, Flaatten H, Guidet B, Szczeklik W; VIP1; VIP2 study group

Critical Care. 2021-07-01

Steroid use in elderly critically ill COVID-19 patients

Jung C, Wernly B, Fjølner J, Bruno RR, Dudzinski D, Artigas A, Pinto BB, Schefold JC, Wolff G, Kelm M, Beil M, Sigal S, van Heerden PV, Szczeklik W, Czuczwar M, Elhadi M, Joannidis M, Oeyen S, Zafeiridis T, Marsh B, Andersen FH, Moreno R, Cecconi M, Leaver S, Boumendil A, De Lange DW, Guidet B, Flaatten H; COVIP study group

European Respiratory Journal. 2021-06-25

Provision of critical care for the elderly in Europe: a retrospective comparison of national healthcare frameworks in intensive care units

Wernly B, Beil M, Bruno RR, Binnebössel S, Kelm M, Sigal S, van Heerden PV, Boumendil A, Artigas A, Cecconi M, Marsh B, Moreno R, Oeyen S, Bollen Pinto B, Szczeklik W, Leaver S, Walther SM, Schefold JC, Joannidis M, Fjølner J, Zafeiridis T, de Lange D, Guidet B, Flaatten H, Jung C; VIP2 study group

British Medical Journal Open. 2021-06-03

Frailty and survival in elderly intensive care patients in Norway

Andersen FH, Ariansen Haaland Ø, Klepstad P, Flaatten H

Acta Anaesthesiol Scand. 2021-04-25

The impact of frailty on survival in elderly intensive care patients with COVID-19: the COVIP study

Jung C, Flaatten H, Fjølner J, Bruno RR, Wernly B, Artigas A, Bollen Pinto B, Schefold JC, Wolff G, Kelm M, Beil M, Sviri S, van Heerden PV, Szczeklik W, Czuczwar M, Elhadi M, Joannidis M, Oeyen S, Zafeiridis T, Marsh B, Andersen FH, Moreno R, Cecconi M, Leaver S, Boumendil A, De Lange DW, Guidet B; COVIP study group.

Critical Care. 2021-04-20;Apr 19;149

Frailty is associated with long-term outcome in patients with sepsis who are over 80 years old: results from an observational study in 241 European ICUs

Haas LEM, Boumendil A, Flaatten H, Guidet B, Ibarz M, Jung C, Moreno R, Morandi A, Andersen FH, Zafeiridis T, Walther S, Oeyen S, Leaver S, Watson X, Boulanger C, Szczeklik W, Schefold JC, Cecconi M, Marsh B, Joannidis M, Nalapko Y, Elhadi M, Fjølner J, Artigas A, de Lange DW; VIP2 study group

Age and ageing. 2021-03-23

PubmedVIP2

Reliability of the Clinical Frailty Scale in very elderly ICU patients: a prospective European study

Flaatten H, Guidet B, Andersen FH, Artigas A, Cecconi M, Boumendil A, Elhadi M, Fjølner J, Joannidis M, Jung C, Leaver S, Marsh B, Moreno R, Oeyen S, Nalapko Y, Schefold JC, Szczeklik W, Walther S, Watson X, Zafeiridis T, de Lange DW

Annals of intensive care. 2021-02-03;11

Frailty as a Prognostic Indicator in Intensive Care

Jung C, Bruno RR, Wernly B, Wolff G, Beil M, Kelm M

Deutsches Ärzteblatt international. 2021-01-04;117;668-673

Disease-course adapting machine learning prognostication models in critically ill elderly COVID-19 patients: a multi-centre cohort study with external validation

Jung C, Mamandipoor B, Fjølner J, Bruno R, Wernly B, Artigas A, Bollen Pinto B, Schefold JC, Wolff G, Kelm M, Beil M, Sviri S, van Heerden PV, Szczeklik W, Czuczwar M, Elhadi M, Joannidis M, Oeyen S, Zafeiridis T, Marsh B, Andersen FH, Moreno R, Cecconi M, Leaver S, De Lange DW, Guidet B, Flaatten H, Osmani V

Journal of medical internet research. 2020-12-04

Sex-specific outcome disparities in very old patients admitted to intensive care medicine: a propensity matched analysis

Wernly B, Bruno RR, Kelm M, Boumendil A, Morandi A, Andersen FH, Artigas A, Finazzi S, Cecconi M, Christensen S, Faraldi L, Lichtenauer M, Muessig JM, Marsh B, Moreno R, Oeyen S, Öhman CA, Pinto BB, Soliman IW, Szczeklik W, Niederseer D, Valentin A, Watson X, Leaver S, Boulanger C, Walther S, Schefold JC, Joannidis M, Nalapko Y, Elhadi M, Fjølner J, Zafeiridis T, De Lange DW, Guidet B, Flaatten H, Jung C; VIP2 Study Group.

Scientific reports. 2020-11-01;10

The wave of very old people in the intensive care unit-A challenge in decision-making

van Heerden PV, Sviri S, Beil M, Szczeklik W, de Lange D, Jung C, Guidet B, Leaver S, Rhodes A, Boumendil A, Flaatten H

J Crit Care. 2020-09-10;Sep 10;290-293

Prognostication in older ICU patients: mission impossible?

Flaatten H, Beil M, Guidet B

Br J Anaesth. 2020-08-14;125;655-657

Elderly Patients in the Intensive Care Unit

Flaatten H, Beil M, Guidet B

Semin Respir Crit Care Med. 2020-08-01;17(01)

Therapy limitation in octogenarians in German intensive care units is associated with a longer length of stay and increased 30 days mortality: A prospective multicenter study

Bruno RR, Wernly B, Beil M, Muessig JM, Rahmel T, Graf T, Meybohm P, Schaller SJ, Allgäuer S, Franz M, Westphal JG, Barth E, Ebelt H, Fuest K, Horacek M, Schuster M, Dubler S, Schering S, Wolff G, Steiner S, Rabe C, Dieck T, Lauten A, Sacher AL, Brenner T, Bloos F, Jánosi RA, Simon P, Utzolino S, Kelm M, De Lange DW, Guidet B, Flaatten H, Jung C

J Crit Care. 2020-08-01;60;58-63

PubmedVIP1VIP2

Comments to "Frailty is associated with hospital readmission in geriatric patients: a prognostic study" : Assessment of frailty in geriatric patients: let's keep it simple

Bruno RR, Wernly B, Guidet B, Flaatten H, De Lange DW, Jung C

Eur Geriatr Med. 2020-07-18;Jul18

Inhibitors of the Renin-Angiotensin-Aldosterone System and Covid-19 in critically ill elderly patients

Jung C, Bruno RR, Wernly B, Joannidis M, Oeyen S, Zafeiridis T, Marsh B, Andersen FH, Moreno R, Fernandes AM, Artigas A, Pinto BB, Schefold J, Wolff G, Kelm M, De Lange DW, Guidet B, Flaatten H, Fjølner J

European heart journal. Cardiovascular pharmacotherapy. 2020-07-09;Jul 9

PubmedCOVIP

Frailty assessment in very old intensive care patients: the Hospital Frailty Risk Score answers another question

Bruno RR, Guidet B, Wernly B, Flaatten H, Jung C

Intensive Care Med. 2020-07-01;46;4847-1515

The good, the bad and the ugly: pandemic priority decisions and triage

Flaatten H, Van Heerden V, Jung C, Beil M, Leaver S, Rhodes A, Guidet B, deLange DW

Journal of Medical Ethics. 2020-06-10

Sepsis at ICU Admission Does Not Decrease 30-day Survival in Very Old Patients: A Post-Hoc Analysis of the VIP1 Multinational Cohort Study

Ibarz M, Boumendil A, Haas LEM, Irazabal M, Flaatten H, de Lange DW, Morandi A, Andersen FH, Bertolini G, Cecconi M, Christensen S, Faraldi L, Fjølner J, Jung C, Marsh B, Moreno R, Oeyen S, Öhman CA, Bollen Pinto B, Soliman IW, Szczeklik W, Valentin A, Watson X, Zaferidis T, Guidet B, Artigas A; VIP1 study

Annals of intensive care. 2020-05-13;10

PubmedVIP1

The contribution of frailty, cognition, activity of daily life and comorbidities on outcome in acutely admitted patients over 80 years in European ICUs: the VIP2 study. Intensive care medicine

Guidet B, de Lange DW, Boumendil A, Leaver S, Watson X, Boulanger C, Szczeklik W, Artigas A, Morandi A, Andersen F), Zafeiridis T), Jung C), Moreno R), Walther S, Oeyen S, Schefold JC, Cecconi M, Marsh B, Joannidis M, Nalapko Y, Elhadi M, Fjølner J, Flaatten H; VIP2 study group.

Intensive Care Medicine. 2019-11-29;46;57-69

Validation of the clinical frailty score (CFS) in French language

Abraham P, Courvoisier DS, Annweiler C, Lenoir C, Millien T, Dalmaz F, Flaatten H, Moreno R, Christensen S, de Lange DW, Guidet B, Bendjelid K, Walder B, Bollen Pinto B

BMC Geriatr. 2019-11-21;19;322

Frailty increases mortality among patients ≥80 years old treated in Polish ICUs

Fronczek J, Polok KJ, Nowak-Kózka I, Włudarczyk A, Górka J, Czuczwar M, Krawczyk P, Ziętkiewicz M, Nowak ŁR, Żukowski M, Kotfis K, Cwyl K, Gajdosz R, Bohatyrewicz R, Biernawska J, Grudzień P, Nasiłowski P, Popek N, Cyrankiewicz W, Wawrzyniak K, Wnuk M, Maciejewski D, Studzińska D, Bernas S, Piechota M, Machała W, Serwa M, Wujtewicz M, Stefaniak J, Szymkowiak M, Gawda R, Adamik B, Kozera N, Goździk W, Flaatten H, Szczeklik W

Anaesthesiology Intensive Therapy. 2019-10-11;50

The hospital frailty risk score is of limited value in intensive care unit patients

Bruno RR, Wernly B, Flaatten H, Schölzel F, Kelm M, Jung C

Critical Care. 2019-07-02;23;239

Huge variation in obtaining ethical permission for a non-interventional observational study in Europe

de Lange DW, Guidet B, Andersen FH, Artigas A, Bertolini G, Moreno R, Christensen S, Cecconi M, Agvald-Ohman C, Gradisek P, Jung C, Marsh BJ, Oeyen S, Bollen Pinto B, Szczeklik W, Watson X, Zafeiridis T, Flaatten H

BMC Medical Ethics. 2019-06-03;20

A comparison of very old patients admitted to intensive care unit after acute versus elective surgery or intervention

Jung C, Wernly B, Muessig JM, Kelm M, Boumendil A, Morandi A, Andersen FH, Artigas A, Bertolini G, Cecconi M, Christensen S, Faraldi L, Fjølner J, Lichtenauer M, Bruno RR, Marsh B, Moreno R, Oeyen S, Öhman CA, Pinto BB, Soliman IW, Szczeklik W, Valentin A, Watson X, Zafeiridis T, De Lange DW, Guidet B, Flaatten H; VIP1 study group

J Crit Care. 2019-05-02;52;141-148

PubmedVIP1

Cumulative Prognostic Score Predicting Mortality in Patients Older Than 80 Years Admitted to the ICU

de Lange DW, Brinkman S, Flaatten H, Boumendil A, Morandi A, Andersen FH, Artigas A, Bertolini G, Cecconi M, Christensen S, Faraldi L, Fjølner J, Jung C, Marsh B, Moreno R, Oeyen S, Öhman CA, Bollen Pinto B, de Smet AMGA, Soliman IW, Szczeklik W, Valentin A, Watson X, Zafeiridis T, Guidet B; VIP1 Study Group

Journal of the American Geriatrics Society. 2019-04-12;67;1263-1267

PubmedVIP1

How Does Frailty Affect ICU Outcome?

Hans Flaatten, Christian Jung, Helene Vallet, Bertrand Guidet

Current Anesthesiology Reports . 2019-04-01;144-150

Caring for the Critically Ill Patients over 80: A Narrative Review

Guidet Bertrand, Helene Vallet, Jacques Boddaert, Dylan W. de Lange, Alessandro Morandi, Guillaume Leblanc, Antonio Artigas, and Hans Flaatten

Annals of Intensive Care. 2018-11-26

Frailty: We need valid and reliable tools in critical care

Flaatten H, Clegg A

Intensive Care Medicine. 2018-11-01;44;1973‐1975

Frailty Is Associated With an Increased Mortality Among Patients ≥ 80 Years Old Treated in Polish ICUs

Jakub Fronczek, Kamil Jurand Polok, Ilona Nowak-Kózka, Anna Włudarczyk, Jacek Górka, Mirosław Czuczwar, Paweł Krawczyk, Mirosław Ziętkiewicz, Łukasz R Nowak, Maciej Żukowski, Katarzyna Kotfis, Katarzyna Cwyl, Ryszard Gajdosz, Romuald Bohatyrewicz, Jowita Biernawska, Paweł Grudzień, Paweł Nasiłowski, Natalia Popek, Waldemar Cyrankiewicz, Katarzyna Wawrzyniak, Marek Wnuk, Dariusz Maciejewski, Dorota Studzińska, Szymon Bernas, Mariusz Piechota, Waldemar Machała, Marta Serwa, Maria Wujtewicz, Jan Stefaniak, Małgorzata Szymkowiak, Ryszard Gawda, Barbara Adamik, Natalia Kozera, Waldemar Goździk, Hans Flaatten, Wojciech Szczeklik

Anaesthesiology intensive therapy / Anestezjologia intensywna terapia . 2018-09-22;50;245-251

PubmedVIP1

Clinical Frailty Scale (CFS) reliably stratifies octogenarians in German ICUs: a multicentre prospective cohort study

Muessig JM, Nia AM, Masyuk M, Lauten A, Sacher AL, Brenner T, Franz M, Bloos F, Ebelt H, Schaller SJ, Fuest K, Rabe C, Dieck T, Steiner S, Graf T, Jánosi RA, Meybohm P, Simon P, Utzolino S, Rahmel T, Barth E, Schuster M, Kelm M, Jung C.

BMC Geriatrics. 2018-07-13;18;162

Predicting outcomes in very old ICU patients: time to focus on the past?

Flaatten H, Oeyen S, deLange DW

Intensive Care Medicine. 2018-07-02;44;1344-1345

Withholding or withdrawing of life-sustaining therapy in older adults (≥ 80 years) admitted to the intensive care unit

Guidet B, Flaatten H, Boumendil A, Morandi A, Andersen FH, Artigas A, Bertolini G, Cecconi M, Christensen S, Faraldi L, Fjølner J, Jung C, Marsh B, Moreno R, Oeyen S, Öhman CA, Pinto BB, Soliman IW, Szczeklik W, Valentin A, Watson X, Zafeiridis T, De Lange DW; VIP1 study group

Intensive Care Medicine. 2018-05-17;44;1027-1038

Should this elderly patient be admitted to the ICU?

Guidet B, de Lange DW, Flaatten H

Intensive Care Medicine. 2018-01-22;44;1926-1928

The impact of frailty on ICU and 30-day mortality and the level of care in very elderly patients (≥ 80 years)

Flaatten H, De Lange DW, Morandi A, Andersen FH, Artigas A, Bertolini G, Boumendil A, Cecconi M, Christensen S, Faraldi L, Fjølner J, Jung C, Marsh B, Moreno R, Oeyen S, Öhman CA, Pinto BB, Soliman IW, Szczeklik W, Valentin A, Watson X, Zaferidis T, Guidet B; VIP1 study group

Intensive Care Medicine. 2017-09-21;43;1820-1828

PubmedVIP1

The Status of Intensive Care Medicine Research and a Future Agenda for Very Old Patients in the ICU

Moreno R, Christensen S, Joynt GM, Bagshaw SM, Sprung CL, Benoit D, Soares M, Guidet B

Intensive Care Medicine. 2017-09-01;43;1319-1328